BDBM50530448 CHEMBL4441183

SMILES C[C@@H]1N(Cc2ccccc2)C(=O)N(C1=O)c1ccc(cc1)N=[N+]=[N-]

InChI Key InChIKey=YRXQKGLBTVAKSC-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50530448   

TargetSmoothened homolog(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50530448(CHEMBL4441183)
Affinity DataKi:  55nMAssay Description:Displacement of BODIPY-LY from SMO (unknown origin) expressed in HEK293F cells measured after 15 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50530448(CHEMBL4441183)
Affinity DataKi:  55nMAssay Description:Displacement of BODIPY-LY from SMO (unknown origin) expressed in HEK293F cells measured after 15 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50530448(CHEMBL4441183)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at SMO in mouse NIH/3T3 cells harboring Gli-responsive firefly luciferase gene assessed as inhibition of SAG-induced response pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50530448(CHEMBL4441183)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at SMO in mouse NIH/3T3 cells harboring Gli-responsive firefly luciferase gene assessed as inhibition of SAG-induced response pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed