BDBM50531146 CHEMBL4463138

SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1

InChI Key InChIKey=YPBBCOGVFKOTTG-FQEVSTJZSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50531146   

TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50:  12nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50:  12nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531146(CHEMBL4463138)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed