BDBM50531955 CHEMBL4461150

SMILES COC(=O)N[C@@H](C1CCOCC1)C(=O)N1C[C@H](F)C[C@H]1c1ncc([nH]1)-c1ccc2c(ccc3oc4cc(ccc4c(=O)c23)-c2cnc([nH]2)[C@@H]2C[C@@H](F)CN2C(=O)[C@@H](NC(=O)OC)C2CCOCC2)c1

InChI Key InChIKey=FAVCENYTDKBYHL-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50531955   

TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531955(CHEMBL4461150)
Affinity DataEC50:  0.0840nMAssay Description:Inhibition of NS5A in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531955(CHEMBL4461150)
Affinity DataEC50:  0.180nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531955(CHEMBL4461150)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of NS5A in HCV genotype 2b assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50531955(CHEMBL4461150)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of NS5A in HCV genotype 3a assessed as decrease in viral replicationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed