BDBM50532619 CHEMBL4568245

SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@H]3CCN(C3)c3ccnc(NC)n3)cc2C(F)(F)F)CC1

InChI Key InChIKey=MSMMOWGLNAZZPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532619   

TargetCyclin-C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532619(CHEMBL4568245)
Affinity DataIC50: 15nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532619(CHEMBL4568245)
Affinity DataIC50: 15nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532619(CHEMBL4568245)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532619(CHEMBL4568245)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed