BDBM50533724 CHEMBL4448986

SMILES CC(NC(=O)c1ccc(cc1Cl)C(F)(F)F)C1(CCC(F)(F)CC1)N1CCN(CC1)S(=O)(=O)c1cn(C)nn1

InChI Key InChIKey=PQOKXTSDKPMYSU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50533724   

LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 33nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 33.1nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 33.1nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of human glycine transporter-2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of human glycine transporter-2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50533724(CHEMBL4448986)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of human glycine transporter-2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed