BDBM50534995 CHEMBL4095008

SMILES CC[C@@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=IFSDAJWBUCMOAH-OAHLLOKOSA-N

Data  7 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50534995   

LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human CCRF-SB cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human CCRF-SB cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  565nMAssay Description:Inhibition of full length His-tagged human recombinant PI3Kbeta expressed in baculovirus by select screen kinase profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kdelta N836D mutant (unknown origin) expressed in Sf21 cells co-expressing p85 by kinase-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human SU-DHL-5 cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  820nMAssay Description:Inhibition of full length His-tagged human recombinant PI3Kalpha expressed in baculovirus by select screen kinase profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human KARPAS422 cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of full length His-tagged human recombinant PI3Kdelta expressed in baculovirus by select screen kinase profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  396nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataIC50:  89nMAssay Description:Inhibition of full length His-tagged human recombinant PI3Kgamma expressed in baculovirus by select screen kinase profiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human SU-DHL-5 cells assessed as reduction in S6 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50534995(CHEMBL4095008)
Affinity DataEC50:  100nMAssay Description:Inhibition of PI3Kdelta in human KARPAS422 cells assessed as reduction in AktS473 phosphorylation levels by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed