BDBM50535043 CHEMBL4577549

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2c(CS(=O)(=O)C2(C)C)c(n1)N1CCOC[C@@H]1C

InChI Key InChIKey=IZLPVLBNRGPOHA-AWEZNQCLSA-N

Data  5 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50535043   

TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTORC1 in HEK293T/17 cells assessed as reduction in S6RP phosphorylation at Ser-240/244 residue after 2 hrs by sandwich immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  226nMAssay Description:Inhibition of mTOR in human whole blood assessed as reduction in alphaCD3/alphaCD28 and IL-2-induced IFNgamma secretion preincubated for 1 hr followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to mTOR in mixed human HeLa/Jurkat/K562 cell lysate by LC-MS based chemoproteomic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to mTOR in mixed human HeLa/Jurkat/K562 cell lysate by LC-MS based chemoproteomic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTORC2 in HEK293T/17 cells assessed as reduction in Akt phosphorylation at Ser-473 residue after 2 hrs by sandwich immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to mTOR in mixed human HEK293/K562/placenta cell lysate by LC-MS based chemoproteomic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to mTOR in mixed human HEK293/K562/placenta cell lysate by LC-MS based chemoproteomic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cellzome

Curated by ChEMBL
LigandPNGBDBM50535043(CHEMBL4577549)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed