BDBM50535223 CHEMBL4586133

SMILES C(CCOc1ccc(cc1)-c1ccccc1)CCN1CCCCCC1

InChI Key InChIKey=MGNUUPFOORCXCU-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50535223   

TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535223(CHEMBL4586133)
Affinity DataIC50: 9.10nMAssay Description:Antagonist activity at human H3R expressed in HEK293 cells assessed as reduction in R)(-)-alpha methylhistamine-induced inhibition of forskolin-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535223(CHEMBL4586133)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant full length H3R expressed in HEK293 cell membranes incubated for 90 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535223(CHEMBL4586133)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]pyrilamine from human H1 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535223(CHEMBL4586133)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535223(CHEMBL4586133)
Affinity DataKi:  2.18E+4nMAssay Description:Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed