BDBM50535224 CHEMBL4540849

SMILES C(CCOc1ccc(cc1)-c1ccccc1)CCN1CCCCC1

InChI Key InChIKey=RFBPYYRKGLJNEU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50535224   

TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535224(CHEMBL4540849)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human H3R expressed in HEK293 cells assessed as reduction in R)(-)-alpha methylhistamine-induced inhibition of forskolin-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535224(CHEMBL4540849)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant full length H3R expressed in HEK293 cell membranes incubated for 90 mins by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535224(CHEMBL4540849)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535224(CHEMBL4540849)
Affinity DataKi:  1.99E+4nMAssay Description:Displacement of [3H]histamine from human recombinant H4R expressed in CHO cells incubated for 60 mins by microbeta scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed