BDBM50535447 CHEMBL4453318

SMILES Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C

InChI Key InChIKey=CKMFOKUQUOYIOR-UHFFFAOYSA-N

Data  1 KI  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50535447   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetD(1B) dopamine receptor(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50535447(CHEMBL4453318)
Affinity DataEC50:  35nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 rec...More data for this Ligand-Target Pair