BDBM50536555 CHEMBL4532174

SMILES Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1

InChI Key InChIKey=XHJAGCFBPKQPDU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50536555   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 12nMAssay Description:Inhibition of EZH2 histone methyltransferase activity of EZH2/EED/SUZ12 protein complex (unknown origin) using histone H3 peptide as substrate (21 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 12nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 30nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 44nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of EZH1 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536555BDBM50536555(CHEMBL4532174)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed