BDBM50536605 CHEMBL4483642

SMILES CCc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1

InChI Key InChIKey=DXEUMMSHTGEMKJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50536605   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536605BDBM50536605(CHEMBL4483642)
Affinity DataIC50: 73nMAssay Description:Inhibition of EZH2 histone methyltransferase activity of EZH2/EED/SUZ12 protein complex (unknown origin) using histone H3 peptide as substrate (21 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536605BDBM50536605(CHEMBL4483642)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EZH1 histone methyltransferase activity of EZH1/EED/SUZ12/RBBP4/AEBP2 protein complex (unknown origin) using histone H3 peptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed