BDBM50537147 CHEMBL4537625

SMILES CC(C)(C)Cc1cc(no1)-c1onc([C@@H](CCC([O-])=O)CC(=O)Nc2ccc(Cl)cc2Cl)c1C1CC1

InChI Key InChIKey=DGQSIRLZPGLPLS-UHFFFAOYSA-M

Data  6 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50537147   

TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataEC50:  9nMAssay Description:Inhibition of human GAL4-fused RORgamma LBD transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of GAL4-fused human PPARgamma transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of GAL4-fused human RORalpha transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha/RXR-beta/RXR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of GAL4-fused human RXR transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of GAL4-fused human PPARdelta transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50537147(CHEMBL4537625)
Affinity DataIC50: 5.00E+4nMAssay Description:Time-dependent inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed