BDBM50537983 CHEMBL4646281

SMILES FC(F)c1ccc2c(n[nH]c2c1)-c1cc2c(OCCNC(=O)C=C)cc(Cc3ccccc3)cc2[nH]1

InChI Key InChIKey=DHHJVKCNCRIXRE-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50537983   

TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataIC50: 4nMAssay Description:Inhibition of ITK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataKi:  13nMAssay Description:Binding affinity to ITK (unknown origin) using TK as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataEC50:  119nMAssay Description:Inhibition of ITK in anti-CD3/CD28 beads-stimulated human Jurkat cells assessed as reduction in Plcgamma1 phosphorylation incubated for 2 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataIC50: 133nMAssay Description:Inhibition of BTK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataIC50: 155nMAssay Description:Inhibition of LCK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataIC50: 320nMAssay Description:Inhibition of JAK3 (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of EGFR (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed