BDBM50537995 CHEMBL4639739

SMILES C=CC(=O)NCCOc1cc(Cc2ccccc2)cc2[nH]c(cc12)-c1n[nH]c2cc(ccc12)-c1cn[nH]c1

InChI Key InChIKey=LARWIZLZQUNUQG-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50537995   

TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of ITK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataKi:  20nMAssay Description:Binding affinity to ITK (unknown origin) using TK as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataEC50:  133nMAssay Description:Inhibition of ITK in anti-CD3/CD28 beads-stimulated human Jurkat cells assessed as reduction in Plcgamma1 phosphorylation incubated for 2 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataIC50: 186nMAssay Description:Inhibition of BTK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataIC50: 405nMAssay Description:Inhibition of LCK (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataIC50: 447nMAssay Description:Inhibition of JAK3 (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of EGFR (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed