BDBM50538444 CHEMBL4640287

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1ccc(Nc3nc(cn4ccnc34)-c3ccc4cn[nH]c4c3)cc1)O2

InChI Key InChIKey=UBDJWLDNVBIAMQ-OYRHEFFESA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538444   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538444(CHEMBL4640287)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538444(CHEMBL4640287)
Affinity DataEC50:  2.33E+3nMAssay Description:Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538444(CHEMBL4640287)
Affinity DataEC50:  162nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed