BDBM50538601 CHEMBL4649501

SMILES COc1cc2CCN(CCc3ccc(NC(=O)\C=C\c4ccc(Oc5ccc(-c6ccccn6)c(c5)C#N)nc4)cc3)Cc2cc1OC

InChI Key InChIKey=YXRXEFGONUMTKW-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538601   

TargetATP-dependent translocase ABCB1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50538601(CHEMBL4649501)
Affinity DataEC50:  51nMAssay Description:Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as concentration required to show half of DOX IC50 incubated for 48 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50538601(CHEMBL4649501)
Affinity DataIC50: 610nMAssay Description:Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as potentiation of DOX-induced cytotoxicity by measuring DOX IC50 at 1 uM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed