BDBM50539764 CHEMBL4635454

SMILES COC(=C)C(=O)N1CCN(C[C@@H]1CC#N)c1nc(OC[C@@H]2CCCN2C)nc2CN(CCc12)c1cccc2cccc(Cl)c12

InChI Key InChIKey=DFGKZGMPZJULDC-DQEYMECFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50539764   

TargetGTPase KRas(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539764(CHEMBL4635454)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed