BDBM50539815 CHEMBL4640521

SMILES C[C@@H]1CCCC[C@@H]1c1cc(=O)[nH]c2n[nH]c(C)c12

InChI Key InChIKey=ISZNDMVFJQJILW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50539815   

TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 40nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 catalytic domain (850 to 1154 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal His-tagged human JAK3 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal GST-tagged human TYK2 catalytic domain (871 to 1187 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JAK1 in human STAT6-bla-RA1 cells assessed as reduction in IL4-induced STAT6-signalling pre-incubated for 1 hrs before human recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539815(CHEMBL4640521)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed