BDBM50540361 CHEMBL4640369::US11427590, Entry 43-PROV::US20240115574, Entry 43-PROV

SMILES COc1ccc(cc1OC)-c1c(C)nc2c(cc(C)nn12)N1CC[C@H](C1)NC(=O)c1ccccc1

InChI Key InChIKey=MDEXPLFSJLTLJE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50540361   

TargetSphingomyelin phosphodiesterase 3(Human)
Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50540361(CHEMBL4640369 | US11427590, Entry 43-PROV | US2024...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSphingomyelin phosphodiesterase 3(Human)
Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50540361(CHEMBL4640369 | US11427590, Entry 43-PROV | US2024...)
Affinity DataIC50: 1.00E+3nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetSphingomyelin phosphodiesterase 3(Human)
Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50540361(CHEMBL4640369 | US11427590, Entry 43-PROV | US2024...)
Affinity DataIC50: 1.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent