BDBM50540367 CHEMBL4645484::US11427590, Entry 36::US20240115574, Entry 36

SMILES CO[C@H](C(=O)N[C@@H]1CCN(C1)c1cc(C)nn2c(c(C)nc12)-c1ccc(OC)c(OC)c1)c1ccccc1

InChI Key InChIKey=HKJCAIVGNXQKDP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50540367   

TargetSphingomyelin phosphodiesterase 3(Human)
The Johns Hopkins University

US Patent
LigandPNGBDBM50540367(CHEMBL4645484 | US11427590, Entry 36 | US202401155...)
Affinity DataIC50: 400nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetSphingomyelin phosphodiesterase 3(Human)
The Johns Hopkins University

US Patent
LigandPNGBDBM50540367(CHEMBL4645484 | US11427590, Entry 36 | US202401155...)
Affinity DataIC50: 400nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetSphingomyelin phosphodiesterase 3(Human)
The Johns Hopkins University

US Patent
LigandPNGBDBM50540367(CHEMBL4645484 | US11427590, Entry 36 | US202401155...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed