BDBM50541590 CHEMBL4646557

SMILES Fc1ccc(Nc2ccc3c(CCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1ccc[se]1

InChI Key InChIKey=WVDCLKDZJSPZRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541590   

TargetMitogen-activated protein kinase 14(Human)
Federal University of Rio De Janeiro (Ufrj)

Curated by ChEMBL
LigandPNGBDBM50541590(CHEMBL4646557)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of NanoBRET kinase tracer K4 binding to full-length human C-terminal NanoLuc-tagged p38alpha MAPK expressed in HEK293T cells incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Federal University of Rio De Janeiro (Ufrj)

Curated by ChEMBL
LigandPNGBDBM50541590(CHEMBL4646557)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Federal University of Rio De Janeiro (Ufrj)

Curated by ChEMBL
LigandPNGBDBM50541590(CHEMBL4646557)
Affinity DataIC50: 101nMAssay Description:Inhibition of p38alpha MAPK in human whole blood assessed as reduction in LPS-induced TNFalpha production preincubated for 2.5 hrs followed by LPS st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed