BDBM50541591 CHEMBL4648755

SMILES Fc1ccc(Nc2ccc3c(CCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1cccs1

InChI Key InChIKey=ZTHHPUKKLZGEGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50541591   

TargetMitogen-activated protein kinase 14(Human)
Federal University of Rio De Janeiro (Ufrj)

Curated by ChEMBL
LigandPNGBDBM50541591(CHEMBL4648755)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Federal University of Rio De Janeiro (Ufrj)

Curated by ChEMBL
LigandPNGBDBM50541591(CHEMBL4648755)
Affinity DataIC50: 43nMAssay Description:Inhibition of p38alpha MAPK in human whole blood assessed as reduction in LPS-induced TNFalpha production preincubated for 2.5 hrs followed by LPS st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed