BDBM50541645 CHEMBL4642346

SMILES Clc1ccc(cn1)-n1nnc2c1C(=O)c1ccccc1C2=O

InChI Key InChIKey=VCOKEGJCZJHISM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541645   

TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541645(CHEMBL4642346)
Affinity DataIC50: 25nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541645(CHEMBL4642346)
Affinity DataIC50: 27nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins by micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541645(CHEMBL4642346)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed