BDBM50541800 CHEMBL4641092

SMILES CS(=O)(=O)c1sc(c2CC(F)(F)[C@@H](O)c12)-c1cc(Cl)cc(c1)C#N

InChI Key InChIKey=ODNKSLDGFCIXQD-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50541800   

TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541800(CHEMBL4641092)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant His6Gb1-tagged HIF2alpha PAS B domain (240 to 350 residues)/human recombinant His6/FLAG-tagged ARNT PAS B domain (356...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541800(CHEMBL4641092)
Affinity DataIC50: 50nMAssay Description:Inhibition of HIF2-alpha in human 786-0 cells cells harboring HRE-Luc2P reporter construct incubated for 48 hrs by ONE-Glo EX reagent based luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541800(CHEMBL4641092)
Affinity DataKd:  210nMAssay Description:Binding affinity to human recombinant HIF-2alpha (240 to 350 residues) assessed as as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541800(CHEMBL4641092)
Affinity DataIC50: 690nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfected with HRE-luc2P assessed as decrease in luminescence incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541800(CHEMBL4641092)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells assessed as decrease in VEGF production incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed