BDBM50542048 CHEMBL4648100::US11414384, Example 77

SMILES Cn1cc(cn1)-c1ccc2c(n[nH]c2c1)C(=O)C(NCCc1ccc(cc1)C#N)c1ccccc1

InChI Key InChIKey=ORJSKSPGDZAPOU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542048   

LigandPNGBDBM50542048(CHEMBL4648100 | US11414384, Example 77)
Affinity DataIC50: 356nMAssay Description:The p300 HAT domain (residues 1287-1666) was expressed and purified with an N-terminal His tag from Escherichia coli cells. The expressed protein was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542048(CHEMBL4648100 | US11414384, Example 77)
Affinity DataIC50: 570nMAssay Description:Binding affinity to recombinant N-terminal His-tagged EP300 HAT domain (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed