BDBM50542484 CHEMBL4647352

SMILES C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2C(=O)N2CCC(F)(F)CC2)C(=O)NCC(C)(C)O)c(c1F)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=IRDOBELSIZXNOV-UHFFFAOYSA-N

Data  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542484   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542484BDBM50542484(CHEMBL4647352)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to human RORgamma LBD by thermofluor thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542484BDBM50542484(CHEMBL4647352)
Affinity DataEC50:  497nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542484BDBM50542484(CHEMBL4647352)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to human RORbeta by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed