BDBM50542499 CHEMBL4635866

SMILES CC(C)(O)CNC(=O)c1nc(C(=O)N2CCC(F)(F)CC2)c(s1)-c1ccc(c(Cl)c1Cl)S(=O)(=O)NC1(CC1)C(F)(F)F

InChI Key InChIKey=XXZBHRMCJRHASA-UHFFFAOYSA-N

Data  1 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50542499   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542499(CHEMBL4635866)
Affinity DataKd:  0.0780nMAssay Description:Binding affinity to human RORgamma LBD by thermofluor thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542499(CHEMBL4635866)
Affinity DataIC50: 8.20nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542499(CHEMBL4635866)
Affinity DataEC50:  68nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542499(CHEMBL4635866)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human RORbeta by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed