BDBM50542535 CHEMBL4645338

SMILES CCN(C1CCC1)C(=O)c1nc(sc1-c1ccc(c(Cl)c1Cl)S(=O)(=O)N[C@@H](C)C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=GQVQGLYCTUATAE-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542535   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542535(CHEMBL4645338)
Affinity DataKd:  0.530nMAssay Description:Binding affinity to human RORgamma LBD by thermofluor thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542535(CHEMBL4645338)
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human RORgammat LBD by M1H cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542535(CHEMBL4645338)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to human RORbeta by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed