BDBM50542737 CHEMBL4645908

SMILES CC(C)c1cc(CCOc2c(Cl)cccc2C(O)=O)cc(c1)-c1ccc2OC[C@@H](N)c2c1

InChI Key InChIKey=HMEJIACTKDVITD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50542737   

TargetCoagulation factor XI(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 15nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 21nMAssay Description:Inhibition of PKL (unknown origin) using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 930nMAssay Description:Inhibition of human uPA using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of human tPa using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of N-terminal human plasma F11a catalytic domain expressed in Escherichia coli strain BL21(DE3) using D-Leu-Pro-Arg*Rh110-D-Pro as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of human thrombin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human F9a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of human F10a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of human F7a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human plasmin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542737(CHEMBL4645908)
Affinity DataIC50: 3.42E+4nMAssay Description:Inhibition of human complement FD by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed