BDBM50544378 CHEMBL4639111

SMILES Clc1ccccc1-c1cc(no1)C(=O)N[C@H]1CN(C[C@@H]1C(=O)N[C@H]1CCCNC1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=DRITZQUGSDWNJE-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50544378   

TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataIC50: 251nMAssay Description:Displacement of [3H]DAMGO from recombinant human MOR measured after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataIC50: 794nMAssay Description:Displacement of [3H]U69593 from KOR (unknown origin) measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 10 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataIC50: 2.51E+4nMAssay Description:Antagonist activity at rat KOR expressed in CHOK1 cells assessed as inhibition of U50488-induced increase in cAMP accumulation measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at rat KOR expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 10 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human MOR expressed in CHOK1 cells assessed as inhibition of DAMGO-induced increase in cAMP accumulation measured after 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed