BDBM50546993 CHEMBL4748782::US11247971, Cmpd ID 408::US11752138, Compound 249

SMILES Cc1ccc(s1)C#Cc1cc(ccc1F)-c1nn(c(CC2CC2)c1Cc1ccc(c(F)c1)S(N)(=O)=O)-c1nc(cs1)C(O)=O

InChI Key InChIKey=ADUJCIPBWYSFQX-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546993   

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataKd:  0.0667nMAssay Description:Binding affinity to human His-tagged LDHA by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataIC50: 106nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataIC50: 403nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546993(CHEMBL4748782 | US11247971, Cmpd ID 408 | US117521...)
Affinity DataIC50: 873nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed