BDBM50547369 CHEMBL4759438

SMILES Cc1c(C(=O)Nc2ccc(cc2F)C(O)=O)c2cc(Br)ccc2c(=O)n1-c1ccccc1

InChI Key InChIKey=IYXVIZFMCZGPTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547369   

TargetProstaglandin F2-alpha receptor(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50547369(CHEMBL4759438)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50547369(CHEMBL4759438)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed