BDBM50547438 CHEMBL4752523

SMILES O=C(Nc1c2CCCc2cc2CCCc12)NS(=O)(=O)\C=C\c1nccs1

InChI Key InChIKey=BHWDYFGTRWGKRI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50547438   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50547438BDBM50547438(CHEMBL4752523)
Affinity DataIC50: 24nMAssay Description:Inhibition of NLRP3 inflammasome activation in human THP1 cells assessed as inhibition of IL-1beta release in presence of MSUMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50547438BDBM50547438(CHEMBL4752523)
Affinity DataIC50: 26nMAssay Description:Inhibition of NLRP3 inflammasome activation in human THP1 cells assessed as inhibition of IL-1beta release in presence of nigericinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50547438BDBM50547438(CHEMBL4752523)
Affinity DataIC50: 35nMAssay Description:Inhibition of NLRP3 in human THP1 cells assessed as inhibition of IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed