BDBM50547793 CHEMBL4741218

SMILES C[C@@H]1CCN(C[C@H]1c1cc(nc2ncnn12)C(F)F)c1cc(ccn1)-c1ccccc1

InChI Key InChIKey=GMXQOYPSMSJQRK-CRAIPNDOSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50547793   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50:  813nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Human)
Janssen Pharmaceutica N. V.

Curated by ChEMBL
LigandPNGBDBM50547793(CHEMBL4741218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed