BDBM50547793 CHEMBL4741218
SMILES C[C@@H]1CCN(C[C@H]1c1cc(nc2ncnn12)C(F)F)c1cc(ccn1)-c1ccccc1
InChI Key InChIKey=GMXQOYPSMSJQRK-CRAIPNDOSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50547793
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica N. V.
Curated by ChEMBL
Janssen Pharmaceutica N. V.
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Janssen Pharmaceutica N. V.
Curated by ChEMBL
Janssen Pharmaceutica N. V.
Curated by ChEMBL
Affinity DataIC50: 813nMAssay Description:Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes by LC-MS analysisMore data for this Ligand-Target Pair