BDBM50547924 CHEMBL4750365::US12441703, Compound 309

SMILES COc1c(F)c(OC(F)(F)F)ccc1Oc1cc(Cl)c(C)c(F)c1C(=O)Nc1ccnc(c1)C(N)=O

InChI Key InChIKey=RLZFZNTUHCVLMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547924   

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547924(CHEMBL4750365 | US12441703, Compound 309)
Affinity DataIC50: 1.40nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547924(CHEMBL4750365 | US12441703, Compound 309)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed