BDBM50547974 CHEMBL4747176

SMILES Cn1cc(cn1)-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N)c2c1

InChI Key InChIKey=WOWJTCSBNCGRMH-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547974   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Paraza Pharma

Curated by ChEMBL

LigandBDBM50547974(CHEMBL4747176)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Competitive inhibition of IRE1alpha LKR domain (Q470 to L997 residues) (unknown origin) expressed in Sf9 insect cells using mini-XBP-1 stem-loop RNA ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
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TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Paraza Pharma

Curated by ChEMBL

LigandBDBM50547974(CHEMBL4747176)Copy SMILESCopy InChI

Affinity DataIC50: 280nMAssay Description:Inhibition of IRE1alpha (unknown origin) assessed as XBP-1 slicing luciferase activity incubated for 1 hr followed by stimulation with thapsigargin m...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL