BDBM50550678 CHEMBL4783168

SMILES FC(F)CN1CC[C@H](C1)Oc1ccc2Sc3c(Cc2c1)cccc3-c1cc(=O)cc(o1)N1CCOCC1

InChI Key InChIKey=VYPJIEHUDAVBLF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50550678   

TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550678(CHEMBL4783168)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550678(CHEMBL4783168)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550678(CHEMBL4783168)
Affinity DataIC50: 180nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550678(CHEMBL4783168)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ATR in human HeLa cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed