BDBM50550824 CHEMBL4797181

SMILES COc1ccc(cc1)C(=O)Nc1nc(c(s1)C(=O)c1ccc(C)cc1)-c1ccccc1

InChI Key InChIKey=QWYBNZBBHWLLPB-UHFFFAOYSA-N

Data  11 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50550824   

TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.0709nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50: 0.0756nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50: 0.0763nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.529nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.529nMAssay Description:Displacement of [3H]CCPA from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR assessed as GTP shiftMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human adenosine A3A receptor measured by radioligand-based affinity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]PSB-603 from rat adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]MSX2 from adenosine receptor A2A in rat brain striatum membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from rat adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed