BDBM50551188 CHEMBL4778826

SMILES COc1ccc(\C=C\C(=O)c2nnn(c2C)-c2ccc(Cl)cc2)cc1OC

InChI Key InChIKey=YOJHPSLHBFFDDL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50551188   

TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 134nMAssay Description:Inhibition of NFkappaB p65 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 388nMAssay Description:Inhibition of VEGFR2 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of HDAC1 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of HDAC2 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HDAC3 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50: 9.99E+5nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed