BDBM50551190 CHEMBL4745240

SMILES Nc1ccccc1NC(=O)Cc1ccc(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=DYZDPPLEIVDWAH-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50551190   

TargetHistone deacetylase 2(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 10 mins followed by addition of substrate fluor De Lys green measured after 30 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human full length CDK2/cyclin A2 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of recombinant human full length CDK1/cyclin A2 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of human recombinant HDAC1 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK7/cyclin H1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC6 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK6/cyclin D3 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 complex preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK4/cyclin D1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50551190BDBM50551190(CHEMBL4745240)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC8 preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescent plate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed