BDBM50552697 CHEMBL4780798

SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12

InChI Key InChIKey=RVFYCRCCTDEQQD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50552697   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552697(CHEMBL4780798)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552697(CHEMBL4780798)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552697(CHEMBL4780798)
Affinity DataIC50: 19nMAssay Description:Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552697(CHEMBL4780798)
Affinity DataIC50: 130nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552697(CHEMBL4780798)
Affinity DataIC50: 570nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed