BDBM50553483 CHEMBL4756595::US20230416221, Compound BAY1251152

SMILES COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F

InChI Key InChIKey=YZCUMZWULWOUMD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553483   

TargetCyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553483(CHEMBL4756595 | US20230416221, Compound BAY1251152)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9 [L156F](Homo sapiens (Human))
Hefei Institutes of Physical Science, Chinese Academy of Sciences

US Patent
LigandPNGBDBM50553483(CHEMBL4756595 | US20230416221, Compound BAY1251152)
Affinity DataIC50:  1.25E+3nMAssay Description:The DMSO diluted compounds and the control compounds Dinaciclib, JSH-009, BAY-1211152, AZD4573 (all purchased from MCE, China) were mixed with the de...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Hefei Institutes of Physical Science, Chinese Academy of Sciences

US Patent
LigandPNGBDBM50553483(CHEMBL4756595 | US20230416221, Compound BAY1251152)
Affinity DataIC50:  12.3nMAssay Description:The DMSO diluted compounds and the control compounds Dinaciclib, JSH-009, BAY-1211152, AZD4573 (all purchased from MCE, China) were mixed with the de...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Hefei Institutes of Physical Science, Chinese Academy of Sciences

US Patent
LigandPNGBDBM50553483(CHEMBL4756595 | US20230416221, Compound BAY1251152)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed