BDBM50553684 CHEMBL4764922

SMILES CN(C)C(=O)c1ccc(Oc2nc(nc(n2)-c2ccnc3[nH]ccc23)N2CCOCC2)cc1

InChI Key InChIKey=OQHLRBUFWDMIIG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50553684   

LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed