BDBM50553821 CHEMBL4741134

SMILES CCOc1ccc(cc1)-n1nnc2cnc(Nc3cnn(c3)C3CCN(C)CC3)nc12

InChI Key InChIKey=GYJNFCRUTKYKNV-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50553821   

TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553821(CHEMBL4741134)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK3 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553821(CHEMBL4741134)
Affinity DataKd:  23nMAssay Description:Binding affinity to wild-type human partial length ERK3 (M1 to P413 residues) expressed in bacterial expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553821(CHEMBL4741134)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 471 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553821(CHEMBL4741134)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant full length His6-GST fusion tagged ERK3 (1 to 721 residues) (unknown origin) using MK5 K51A mutant as substrate by ADP-Glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553821(CHEMBL4741134)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 365 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed