BDBM50553825 CHEMBL4753751

SMILES COc1ccc(cc1)-n1nnc2cnc(N[C@@H]3CC[C@H](N)C3)nc12

InChI Key InChIKey=OSHLPUOBFBCDRP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553825   

TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553825(CHEMBL4753751)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant full length His6-GST fusion tagged ERK3 (1 to 721 residues) (unknown origin) using MK5 K51A mutant as substrate by ADP-Glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553825(CHEMBL4753751)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 471 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553825(CHEMBL4753751)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 365 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553825(CHEMBL4753751)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of ERK3 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed