BDBM50554088 CHEMBL4741060

SMILES COc1nc(ccc1-n1cnc(C)c1)-c1csc(Nc2c3CCCCc3nn2CCO)n1

InChI Key InChIKey=BIJIJDJQJHEOKP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50554088   

TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 144nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554088(CHEMBL4741060)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed