BDBM50555296 CHEMBL4753893::US11306078, Example 1.186

SMILES CN(C)C(=O)[C@@H]1CN(CC[C@H]1NC(=O)c1cc(on1)-c1ccc(F)cc1F)C1CCCCC1

InChI Key InChIKey=WTQZMARGZPHBHA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50555296   

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555296(CHEMBL4753893 | US11306078, Example 1.186)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in CHO-K1 cells co-expressing beta-arrestin assessed as reduction in compound-1 induced respo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555296(CHEMBL4753893 | US11306078, Example 1.186)
Affinity DataIC50: 37nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
US Patent

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555296(CHEMBL4753893 | US11306078, Example 1.186)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555296(CHEMBL4753893 | US11306078, Example 1.186)
Affinity DataIC50: 66nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
US Patent

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555296(CHEMBL4753893 | US11306078, Example 1.186)
Affinity DataIC50: 162nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
US Patent