BDBM50555786 CHEMBL4782130

SMILES FC(F)(F)c1cc2Nc3nc(NCCCCCOC(=O)c(c2)c1)nc(n3)-c1cccc(n1)C(F)(F)F

InChI Key InChIKey=LUGOCBFCKUBNQN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50555786   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555786(CHEMBL4782130)
Affinity DataIC50: 105nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555786(CHEMBL4782130)
Affinity DataIC50: 314nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555786(CHEMBL4782130)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed