BDBM50557552 CHEMBL4747958

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(c2ccccc12)S(=O)(=O)N(C)C

InChI Key InChIKey=VLMFINHKLSUJLY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50557552   

TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50557552(CHEMBL4747958)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant using biotinylated TK peptide as substrate measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50557552(CHEMBL4747958)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50557552(CHEMBL4747958)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50557552(CHEMBL4747958)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using biotinylated TK peptide as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed